The effects of angiotensin-converting enzyme-inhibitory peptide LAP on the left common carotid artery remodeling in spontaneously hypertensive rats.


OBJECTIVE: To investigate the protective effect of angiotensin-converting enzyme (ACE)-inhibitory peptide LAP on the left common carotid artery remodeling in spontaneously hypertensive rats (SHRs). METHODS: A cohort of male SHRs were randomly divided into three groups (n = 10 for each group): pseudo-experimental group, enalapril-treated group as a positive control group, ACE-inhibitory peptide LAP-treated group. After the experiment, the left common carotid artery from each rat was removed for morphological evaluation. RESULTS: It was observed that the vascular medial thickness, media thickness/lumen diameter, medial cross-sectional area and mean nuclear area of smooth muscle cells of the left common carotid artery in the LAP group or enalapril group were significantly lower than those in the pseudo-experimental group, while there was no significant difference in these parameters observed between the LAP group and enalapril group. Additionally, the vascular area percentage of collagen fibers of the left common carotid artery in the LAP group and enalapril group was significantly lower than that of the pseudo-experimental group. CONCLUSIONS: The protective vessel remodeling effect in SHRs was observed with ACE-inhibitory peptide LAP in SHRs by decreasing blood pressure, inhibiting smooth muscle cell hypertrophy and reducing the proliferation of collagen fibers.

date published: 2013 Dec
article identifier: ['10.1007/s11845-013-0963-5 [doi]']
location identifier: 10.1007/s11845-013-0963-5 [doi]
entrez date: 2013-05-11
registry mumbers: ['0 (Angiotensin-Converting Enzyme Inhibitors)', '0 (Antihypertensive Agents)', '0 (Fibrillar Collagens)', '0 (Peptides)', '69PN84IO1A (Enalapril)']
publication history status: ['2012/03/26 [received]', '2013/04/24 [accepted]']
volume: 182
date completed: 2014-06-30
pages: 711-8
journal: Irish journal of medical science
affiliation: Department of Cardiology, Tongji Hospital Affiliated to Tongji University, Shanghai, 200065, China.
language: ['eng']
publication status: ppublish
owner: NLM
mesh date: 2014-07-01
date last revision: 20130510
origin: PubMed
date created: 2013-10-18
nlm unique id: 7806864
pmid: 23661144
authors: ['Hong, F', 'Junling, H', 'Yi, S', 'Chi, L', 'Huan, Z', 'Yu Qing, D', 'Lingxia, L', 'Yang, G', 'Ming, L']
publication type: ['Comparative Study', 'Journal Article']
issue: 4
status: MEDLINE
journal title abbreviation: Ir J Med Sci
source: Ir J Med Sci. 2013 Dec;182(4):711-8. doi: 10.1007/s11845-013-0963-5. Epub 2013 May 10.
mesh terms: ['Angiotensin-Converting Enzyme Inhibitors/*pharmacology', 'Animals', 'Antihypertensive Agents/*pharmacology', 'Blood Pressure/drug effects', 'Carotid Artery, Common/*drug effects/enzymology/pathology', 'Carotid Intima-Media Thickness', 'Cell Proliferation/drug effects', 'Disease Models, Animal', 'Enalapril/pharmacology', 'Fibrillar Collagens/metabolism', 'Heart Rate/drug effects', 'Hypertension/*drug therapy/enzymology/physiopathology', 'Hypertrophy', 'Male', 'Muscle, Smooth, Vascular/drug effects/pathology', 'Peptides/*pharmacology', 'Rats', 'Rats, Inbred SHR']
subset: IM

Reference: .. [Hong+Al:2013] Hong, F; Junling, H; Yi, S; Chi, L; Huan, Z; Yu Qing, D; Lingxia, L; Yang, G; & Ming, L (2013). '**The effects of angiotensin-converting enzyme-inhibitory peptide LAP on the left common carotid artery remodeling in spontaneously hypertensive rats.**' *Irish journal of medical science*. 182(4), pp. 711-8.