Bidentate P, N-P Ligand for nickel-catalyzed cross-coupling of aryl or benzyl chlorides with ArMgX.


A cross-coupling reaction of a variety of aryl, heteroaryl, and benzyl chlorides with ArMgX is catalyzed by 2 mol % of a nickel-phosphine complex prepared in situ from an equimolar amount of Ni(CH(3)CN)(2)Cl(2) and ligand (L2) to yield products in excellent yield in THF at room temperature. This new bidentate ligand (L2) is stable in air and forms a stable complex upon reaction with Ni(CH(3)CN)(2)Cl(2). Structures of the ligand and the complex were confirmed by single-crystal X-ray diffraction.

date published: 2010 Dec 03
article identifier: ['10.1021/jo1016458 [doi]']
location identifier: 10.1021/jo1016458 [doi]
entrez date: 2010-11-10
volume: 75
date completed: 2011-02-15
pages: 8283-6
journal: The Journal of organic chemistry
affiliation: Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India.
language: ['eng']
publication status: ppublish
mesh date: 2010-11-10
date last revision: 20101108
origin: PubMed
date created: 2010-11-29
owner: NLM
nlm unique id: 2985193R
pmid: 21058667
authors: ['Ghosh, Raju', 'Sarkar, Amitabha']
publication type: ['Journal Article']
issue: 23
status: PubMed-not-MEDLINE
journal title abbreviation: J Org Chem
source: J Org Chem. 2010 Dec 3;75(23):8283-6. doi: 10.1021/jo1016458. Epub 2010 Nov 8.

Reference: .. [Ghosh+Sarkar:2010] Ghosh, Raju & Sarkar, Amitabha (2010). '**Bidentate P, N-P Ligand for nickel-catalyzed cross-coupling of aryl or benzyl chlorides with ArMgX.**' *The Journal of organic chemistry*. 75(23), pp. 8283-6.